KCNQ1 Monoclonal Antibody - BT-MCA4240

KCNQ1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4240-50, BT-MCA4240-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Cardiovascular, Metabolism, Neuroscience, Signal transduction

Target Protein: KCNQ1

Applications: WB, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5E12

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: KCNQ1

Immunogen: Purified recombinant fragment of human KCNQ1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 95kDa

UniProt Accession: P51787

Synonyms: LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, FLJ26167

GeneID: 3784

Research Use Only