KCNQ1 Polyclonal Antibody - BT-AP10652

KCNQ1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10652-20, BT-AP10652-50, BT-AP10652-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Research Areas: Cardiovascular; Metabolism; Neuroscience; Signal transduction

Target Protein: KCNQ1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Potassium voltage-gated channel subfamily KQT member 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P51787; Mouse: P97414; Rat: Q9Z0N7

Synonyms: Potassium voltage-gated channel subfamily KQT member 1;IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1;KQT-like 1;Voltage-gated potassium channel subunit Kv7.1

GeneID: Human: 3784

Research Use Only