KCTD21 Monoclonal Antibody-MB11140

KCTD21 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11140-50, MB11140-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q4G0X4

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,

All Applications: WB: 1/500-1/1000

Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 30 kDa; Observed MW: 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of KCTD21 in mouse brain, rat brain lysates using KCTD21 antibody., Western blot analysis of KCTD21 in K562 lysates using KCTD21 antibody.

Alternative Name: KCASH2

Immunogen: Recombinant protein of human KCTD21

Conjugate: Unconjugated

Modification: Unmodified