Product Description

KDM1A (1B2) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3134-50, MB3134-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O60341

Host: Mouse

Reactivity: Human, Mouse,Monkey

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of KDM1 / LSD1 in A549 and JurkatLysates using KDM1 / LSD1 antibody.

Bioworld Molecular Weight: Calculated MW: 93 kDa; Observed MW: 93 kDa

Specificity: IgG1

Alternative Name: KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

Immunogen: Purified recombinant fragment of human LSD1 expressed in E. Coli.

Conjugate: Unconjugated

Modification: Unmodified