KDM1A Monoclonal Antibody-MB11143

KDM1A Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11143-50, MB11143-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O60341

Host: Rabbit

Reactivity: Human, Hamster, Rat

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 93 kDa; Observed MW: 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of KDM1/LSD1 in Jurkat lysates using KDM1A antibody., Western blot analysis of KDM1/LSD1 in Hela, CHO-K1, C6, Jurkat lysates using KDM1/LSD1 antibody., Immunocytochemistry analysis of KDM1/LSD1 in Hela using KDM1/LSD1 antibody, and DAPI

Alternative Name: KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

Immunogen: A synthetic peptide of human KDM1/LSD1

Conjugate: Unconjugated

Modification: Unmodified