KDM3A Monoclonal Antibody - BT-MCA3747

KDM3A Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3747-50, BT-MCA3747-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.

Research Areas: Epigenetics and nuclear signaling

Target Protein: KDM3A

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1E12

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: KDM3A

Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 147kDa

UniProt Accession: Q9Y4C1

Synonyms: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A

GeneID: 55818

Research Use Only