KHDR3 rabbit pAb - ES9757

KHDR3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES9757-50, ES9757-100

Citations, Manuals and MSDS Available upon request.

Background: domain:The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase., function:RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression., induction:Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death., PTM:Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated., similarity:Belongs to the KHDRBS family., similarity:Contains 1 KH domain., subcellular location:Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one., subunit:Self-associates to form homo-oligomers. Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1, RBMX, RBMY1A1 and with p85 subunit of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation., tissue specificity:Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 38kD

Human Gene ID: 10656

Human SWISS Prot NO: O75525

Subcellular Location: Nucleus. Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.

Research Use Only