Product Description

KHSRP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS9961M-50, BS9961M-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q92945

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC ICC IP, FC

All Applications: WB: 1:500-1:2000 ICC: 1:50-1:200
IHC: 1:50-1:200 IP: 1:10-1:50

Background: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Purification and Purity: Protein A affinity purified.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of KHSRP and does not cross-react with related proteins.

Bioworld Molecular Weight: ~ 73 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of KHSRP Rabbit mAb at 1:1000 dilution
Lane 1: 293 whole cell lysate
Lane 2: The brain tissue lysate of Mouse
Lane 3: The brain tissue lysate of Rat, Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-KHSRP antibody. Counter stained with hematoxylin., ICC staining KHSRP in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75; KHSRP; FUBP2

Immunogen: Recombinant protein within human KHSRP aa 1-150.

Conjugate: Unconjugated

Modification: Unmodified