KIF7 (2A7) Monoclonal Antibody-MB3179

KIF7 (2A7) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3179-50, MB3179-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q2M1P5

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: IHC-P, ICC/IF

All Applications: IHC: 1/50-1/100 IF: 1/50-1/200

Background: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG1

Bioworld Molecular Weight: -

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunofluorescence analysis of KIF7 in mouse colon using KIF7 antibody, and DAPI., Immunohistochemistry analysis of paraffin-embedded mouse Kidney tissue using KIF7 antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Alternative Name: kinesin like protein KIF7; EQYK340; kif7

Immunogen: Synthetic Peptide of Kif 7

Conjugate: Unconjugated

Modification: Unmodified