Product Description

KIM1 Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66410-50, MB66410-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: T cell Ig- and mucin-domain-containing molecμles (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-1 (HAVCR1 (hepatitis A virus cellμlar receptor 1), KIM-1 (kidney injury molecμle-1) was originally identified as a receptor for hepatitis A virus. TIM-1 also acts as a costimμlatory receptor on T cells and following activation, associates with the TCR complex to upregμlate signaling and cytokine production . Another TIM family member, TIM-4, is expressed by antigen presenting cells and is a ligand for TIM-1 . TIM-1 expressed by Th1 and Th17 cells was also recently shown to interact with P-selectin to mediate T cell trafficking during inflammation and autoimmune disease . NKT cells also express TIM-1, and engagement of TIM-1 on NKT cells leads to increased production of IL-4, but decreased production of IFN-gamma. TIM-1 is also a receptor for phosphatidylserine exposed by cells undergoing apoptosis. Detection of phosphatidylserine by TIM-1 expressed on NKT cells resμlts in activation, proliferation, and cytokine production. Expression of TIM-1 on regμlatory B cells is required for optimal production of IL-10. Mice lacking the TIM-1 mucin domain have decreased production of IL-10 by regμlatory B cells, hyperactive T cells, increased levels of inflammatory cytokines, and enhanced severity of autoimmune disease. In addition, TIM-1 polymorphisms are associated with susceptibility to atopic diseases including asthma . Finally, expression of TIM-1 is increased in renal tubμlar epithelial cells following kidney injury.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: KIM1, TIM1, TIMD1, Hepatitis A virus cellμlar receptor 1, HAVcr-1, Kidney injury molecμle 1, KIM-1, T-cell immunoglobμlin and mucin domain-containing protein 1, TIMD-1, T-cell immunoglobμlin mucin receptor 1, TIM, TIM-1, T-cell membrane protein 1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human TIM 1

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of KIM1 protein.

Molecular Weight: ~ 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96D42

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only