Product Description

Kinectin 1 Polyclonal Antibody

Catalogue Numbers: BS67342-50, BS67342-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q86UP2

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

All Applications: WB (1/500 - 1/2000), IHC (1/50 - 1/200)

Background: Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking. The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly. Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER. Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer, hepatocellular carcinoma (HCC), Parkinson's disease , and the autoimmune syndrome Behçet's disease (BD)

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Kinectin 1 protein.

Extra Notes: Western blot analysis of Kinectin 1 expression in K562 (A), mouse testis (B) whole cell lysates.

Bioworld Molecular Weight: ~ 160 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CG1; KIAA0004; Kinectin; CG-1 antigen; Kinesin receptor

Immunogen: KLH-conjugated synthetic peptide of human Kinectin 1

Conjugate: Unconjugated

Modification: Unmodified