Kininogen 1 Rabbit rabbit pAb - ES20692

Kininogen 1 Rabbit rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20692-50, ES20692-100

Citations, Manuals and MSDS Available upon request.

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014],

Alternate Name: Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]

Source: Rabbit

Applications: WB; IHC

Dilution: IHC-p 1:50-200, WB 1:500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein derived from human Kininogen 1

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 45-120kD

Human Gene ID: 3827

Human SWISS Prot NO: P01042

Subcellular Location: Secreted, extracellular space.

Research Use Only