KIRREL2 Polyclonal Antibody
Catalogue Numbers: BS60707-50, BS60707-100
Sizes: 50µl, 100µl
Alternative Name: Kin of IRRE-like protein 2; Kin of irregular chiasm-like protein 2; Nephrin-like protein 3; KIRREL2NEPH3; UNQ5827; PRO19646
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q6UWL6
Host: Rabbit
Reactivity: Human, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: NEPH3 (nephrin-like protein 3), also referred to as NLG1, FILTRIN or KIRREL2 (kin of IRRE like 2), is a 708 amino acid protein that is a member of the immunoglobulin superfamily of cell adhesion molecules. NEPH3 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues. NEPH3 localizes to the interpodocyte filtration slit in the kidney and to the Langerhans islet beta cells in the pancreas. NEPH3 is thought to be involved in the maintenance of the glomerular filtration barrier in the kidney and in pancreas development. Downregulation of NEPH3 is implicated in several proteinuric diseases. Five isoforms exists due to alternative splicing events.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: KIRREL2 polyclonal antibody detects endogenous levels of KIRREL2 protein.
Bioworld Molecular Weight: ~ 75 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of KIRREL2 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: H9C2 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human KIRREL2
Conjugate: Unconjugated
Modification: Unmodified