Product Description

KLF10/KLF11 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61041-50, BS61041-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Originally isolated from osteoblastic cells, the TGFβ1-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor-encoding gene which regμlates cellμlar growth and differentiation. TIEG1 is regμlated as an early response gene by TGFβ1. It is expressed in both acinar and ductμlar epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cell lines. Further, overexpression of TIEG1 in TGFβ-sensitive epithelial cells induces apoptosis. TIEG1 and EGRa are expressed from alternate promoters of the same gene. Both are highly expressed in human fetal osteoblast cells. TIEG1 is additionally expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal erythroid cells. TIEG2 is also expressed in fetal liver. Overexpression of TIEG2 in cμltured epithelial cells inhibits cellμlar proliferation. TIEG2 expression is upregμlated by TGFβ1 and serum deprivation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Krueppel-like factor 10, EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1, KLF10, TIEG, TIEG1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human KLF10/11.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: KLF10/KLF11 polyclonal antibody detects endogenous levels of KLF10 and KLF11 protein.

Molecular Weight: ~ 14 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13118/O14901

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only