KLHL12 Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA11576-50, RA11576-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: kelch like family member 12 (KLHL12) Homo sapiens This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014], Reactivity: Human Host: Mouse Applications: WB, ELISA Alternate Names: KLHL12, C3IP1, Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR Clonality: Monoclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Human Gene ID: 59349 Research Use Only