Product Description

KLHL3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67621-50, BS67621-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Substrate-specific adapter of a BCR (BTB-Cμl3-RBX1) E3 ubiquitin ligase complex that acts as a regμlator of ion transport in the distal nephron . The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation . The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellμlar chloride transport in the kidney (By similarity).

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: KIAA1129, Kelch-like protein 3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human KLHL3. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of KLHL3 protein.

Molecular Weight: ~ 78 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UH77

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only