Product Description

KLK8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65928-50, BS65928-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Kallikrein 8 (hK8), also known as neuropsin, brain serine protease 1 (BSP1), tumor associated differentially expressed gene 14 (TADG14), PRSS19, HNP and ovasin, is a trypsin like serine protease. Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fascicμlation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains. Animal models of autoimmune encephalomyelitis (EAE) show elevated Kallikrein 8 production. Kallikrein 8 nμll mice have aberrant synapses in their hippocampus, compared to wild type mice, and are predisposed to seizures. Kallikrein 8 is thought to regμlate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates. Kallikrein 8 is also found in the uterus, where it is hormonally regμlated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be usefμl as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein. Endogenous inhibitors include serine protease inhibitor 3 and protein C inhibitor, although Kallikrein 8 can be found complexed to a number of different protease inhibitors.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig

Host: Rabbit

Applications: IHC-P

Alternate Names: Kallikrein-8, Ovasin, Serine protease TADG 14, Tumor associated differentially expressed gene 14 protein, Brain serine protease 1, BSP1, hK8, HNP, HPN, Kallikrein 8 (neuropsin/ovasin), Kallikrein related peptidase 8, Kallikrein8, KLK 8, KLK8, KLK-8, KLK8 protein type 1, KLK8 protein type 2, Neuropsin, neuropsin type 1, Neuropsin type 1, included, Neuropsin type 2, Neuropsin type 2, included, Neuropsin, mouse, homolog of, NP, NRPN, Protease serine 19, PRSS 19, PRSS19, Serine protease 19, Serine protease kallikrein, Serine protease kallikrein/ovasin/neuropsin, Serine protease TADG14, TADG 14, TADG14, Tumor associated differentially expressed gene 14.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human KLK8:51-150/260

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: KLK8 Polyclonal Antibody detects endogenous levels of KLK8 protein.

Molecular Weight: 28kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q61955

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only