KLOTB Polyclonal Antibody - BT-AP10733

KLOTB Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10733-20, BT-AP10733-50, BT-AP10733-100

Citations, Manuals and MSDS Available upon request.

Background: Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive.,Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.,Belongs to the glycosyl hydrolase 1 family.,Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,subunit:Interacts with FGFR1 and FGFR4.,

Research Areas: Metabolism; Signal transduction; Cardiovascular; Epigenetics and nuclear signaling

Target Protein: KLB

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Beta-klotho

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q86Z14; Mouse: Q99N32

Synonyms: Beta-klotho;BKL;BetaKlotho;Klotho beta-like protein

GeneID: Human: 152831

Research Use Only