KMT1B rabbit pAb - ES2678

KMT1B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2678-50, ES2678-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N (6)-methyl-L-lysine., domain:Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin., function:Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis., similarity:Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily., similarity:Contains 1 chromo domain., similarity:Contains 1 post-SET domain., similarity:Contains 1 pre-SET domain., similarity:Contains 1 SET domain., subcellular location:Associates with centromeric constitutive heterochromatin., subunit:Interacts with SMAD5.,

Alternate Name: SUV39H2; KMT1B; Histone-lysine N-methyltransferase SUV39H2; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su (var)3-9 homolog 2

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human SUV39H2. AA range:111-160

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 46kD

Human Gene ID: 79723

Human SWISS Prot NO: Q9H5I1

Subcellular Location: Nucleus. Chromosome, centromere. Associates with centromeric constitutive heterochromatin.

Research Use Only