KMT6/EZH2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90776-50, BS90776-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q15910(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC/IF, IHC
All Applications: WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
Background: In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. ENX-1, a mammalian homolog of the Drosophila gene enhancer of zeste, is a PcG protein that is ubiquitously expressed during early embryogenesis and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, ENX-1 is restricted to specific sites, including spleen, testis and placenta. The gene encoding human ENX-1 transcribes a 746 amino acid polypeptide which contains a trithorax-like domain and a DNA-binding motif. ENX-1 interacts with the proto-oncogene product Vav and is thought to be involved in the proliferation of normal and malignant hematopoietic cells. By altering the regulation of target genes, ENX-1 may also contribute to certain phenotypes of Down syndrome.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: KMT6/EZH2 polyclonal antibody detects endogenous levels of KMT6/EZH2 protein.
Bioworld Molecular Weight: 86 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of KMT6/EZH2 on different lysates using anti-KMT6/EZH2 antibody at 1/1,000 dilution.
Positive control:
Lane 1: 293T
Lane 2: 293, ICC staining KMT6/EZH2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: EZH2, Enhancer of zeste 2, enhancer of zeste 2 polycomb repressive complex 2 subunit, Enhancer of zeste homolog 2 (Drosophila), Enhancer of zeste homolog 2, Enhancer of zeste, Drosophila, homolog 2, ENX 1, Enx 1h, ENX-1, ENX1, Enx1h, EZH 2, EZH1, EZH2, EZH2, EZH2b, Histone-lysine N-methyltransferase EZH2, KMT 6, KMT6, KMT6A, Lysine N-methyltransferase 6, MGC9169, WVS, WVS2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified