[KO Validated] NCOA2 Rabbit pAb - A10280

[KO Validated] NCOA2 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A10280-20, A10280-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, ELISA

Cross-reactivity: Human, Rat

Protein Weight: 159kDa

Observed Molecular Weight: 200kDa

Immunogen: Recombinant protein (or fragment)

Species: Human

GeneID: 10499

SWISS: Q15596

Alternate Names: SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75; A2

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Nuclear Receptor Signaling, Cancer, Endocrine Metabolism, Lipid Metabolism, Endocrine and metabolic diseases, Obesity.

NCBI Alias: NCOA2

Research Use Only