KOR-1 rabbit pAb - ES6445

KOR-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6445-50, ES6445-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],

Alternate Name: OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 48kD

Human Gene ID: 4986

Human SWISS Prot NO: P41145

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Research Use Only