Product Description

KOR-1(Ab-369)Polyclonal Antibody

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65124-50, BS65124-100

Swiss-Prot: P41145

Host: Rabbit

KOR-1(Ab-369)Polyclonal Antibody-BS65124

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Monkey

Applications: WB, ELISA

All Applications: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Background: opioid receptor kappa 1(OPRK1) Homo sapiens This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.

Bioworld Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis ofLysates from COS7 cells, using OPRK1 Antibody. The lane on the right is blocked with the synthesized peptide., Western blot analysis of theLysates from HeLa cells using OPRK1 antibody.

Alternative Name: OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1

Immunogen: The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370

Modification: Unmodified

Conjugate: Unconjugated