Product Description

KOX17 (K22) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1938-50, BS1938-100

Sizes: 50µl, 100µl

Swiss-Prot: P17028

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF191 (Zinc finger protein 191), also known as ZNF24, KOX17, ZSCAN3 or RSG-A, is a 368 amino acid nuclear protein that belongs to the Krueppel C2H2-type zinc-finger protein family. Expressed in tissues throughout the body with the exception of heart, ZNF191 functions as a transcriptional repressor for a variety of proteins, such as VEGF (vascular endothelial growth factor), and is thought to be important for early embryonic development and cell proliferation. ZNF191 contains four C2H2-type zinc fingers and one SCAN box domain and, upon DNA damage, may be phosphorylated by ATM or ATR.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: KOX17 (K22) polyclonal antibody detects endogenous levels of KOX17 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of KOX17 (K22) pAb at 1:500 dilution
Lane 1: Hela whole cell lysate (40ug)
Lane 2: HEK293T whole cell lysate (40ug)
Lane 3: A549 whole cell lysate (40ug)
Lane 4: U-87MG whole cell lysate (40ug)
Lane 5: The Brain tissue lysate of Rat (10ug)
Lane 6: PC12 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of KOX17 (K22) pAb in paraffin-embedded human heart tissue.

Bioworld Molecular Weight: ~ 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: KOX17; Retinoic acid suppression protein A; RSG A; RSGA; Zfp191; Zinc finger and SCAN domain containing protein 3; Zinc finger protein 191; Zinc finger protein 24; Zinc finger protein KOX17; ZNF 24; ZNF191; ZSCAN 3; ZSCAN3;

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human KOX17.

Conjugate: Unconjugated

Modification: Unmodified