KPB2 rabbit pAb - ES15272

KPB2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15272-50, ES15272-100

Citations, Manuals and MSDS Available upon request.

Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010],

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human KPB2 AA range: 911-961

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5256

Human SWISS Prot NO: P46019

Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side.

Research Use Only