KPNA6 rabbit pAb - ES15271

KPNA6 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15271-50, ES15271-100

Citations, Manuals and MSDS Available upon request.

Background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008],

Alternate Name: Importin subunit alpha-7 (Karyopherin subunit alpha-6)

Source: Rabbit

Applications: WB; IP

Dilution: WB 1:500-2000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human KPNA6 AA range: 404-454

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 23633

Human SWISS Prot NO: O60684

Subcellular Location: nucleus, nuclear pore, nucleoplasm, cytoplasm, cytosol, membrane,

Research Use Only