KPYR Polyclonal Antibody - BT-AP10748

KPYR Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10748-20, BT-AP10748-50, BT-AP10748-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Research Areas: Cancer; Metabolism; Signal transduction

Target Protein: PKLR

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Pyruvate kinase isozymes R/L

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P30613; Mouse: P53657; Rat: P12928

Synonyms: Pyruvate kinase isozymes R/L;EC 2.7.1.40;Pyruvate kinase 1;R-type/L-type pyruvate kinase;Red cell/liver pyruvate kinase

GeneID: Human: 5313

Research Use Only