Product Description

Ksr2 (I694) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2321-50, BS2321-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Kinase suppressor of Ras (Ksr) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regμlates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr-1 and Ksr-2. Ksr-2 plays a key role in Ras-mediated signaling during germline meiotic progression and functions redundantly with Ksr-1 during the development of the excretory system pathway, hermaphrodite vμlva, and male spicμles. Ksr-2 also functions as a negative regμlator of the MEKK3-mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NF˚B pathways, and it simμltaneously inhibits MEKK3-mediated Il-8 production.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: KSR2, Kinase suppressor of Ras 2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 662-724 of Human Ksr2.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Ksr2 (I694) polyclonal antibody detects endogenous levels of Ksr2 protein.

Molecular Weight: ~ 108 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6VAB6

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only