Product Description

Ku-70 (S1) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1818-50, BS1818-100

Sizes: 50µl, 100µl

Swiss-Prot: P12956

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Ku70 (S1) polyclonal antibody detects endogenous levels of Ku70 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Ku-70 (S1) pAb at 1:500 dilution
Lane 1: MCF-7 whole cell lysate (2.5ug)
Lane 2: HEK293T whole cell lysate (2.5ug)
Lane 3: PC12 whole cell lysate (20ug)
Lane 4: The Kidney tissue lysate of Mouse (40ug)
Lane 5: AML-12 whole cell lysate (40ug)
Lane 6: 3T3-L1 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Ku-70 (S1) pAb in paraffin-embedded liver cancer tissue at 1:100.

Bioworld Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in; Chinese hamster cells 6; XRCC6; G22P1

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Ku-70.

Conjugate: Unconjugated

Modification: Unmodified