Ku-80 Polyclonal Antibody - BT-AP04902

Ku-80 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP04902-20, BT-AP04902-50, BT-AP04902-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by XRCC5 (X-ray repair cross complementing 5) is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. XRCC5 functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: XRCC5

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Monkey

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Ku-80 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 82705

UniProt Accession: Human: P13010; Mouse: P27641

Synonyms: XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85

GeneID: Human: 7520

Research Use Only