Product Description

Kv1.1 Polyclonal Antibody

Catalogue Numbers: BS5777-50, BS5777-100

Sizes: 50µl, 100µl

Alternative Name: Potassium voltage-gated channel subfamily A member 1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1L Voltage-gated potassium channel subunit Kv1.1; KCNA1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q09470

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Kv1.1 polyclonal antibody detects endogenous levels of Kv1.1 protein.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Kv1.1 pAb at 1:500 dilution
Lane 1: The Brain tissue lysate of Mouse(40ug)
Lane 2: The Brain tissue lysate of Rat(40ug)
Lane 3: A2780 whole cell lysate(40ug)
Lane 4: L02 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 298-343 of Human Kv1.1.

Conjugate: Unconjugated

Modification: Unmodified