Kv1.1 Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS90780-50, BS90780-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: Q09470(Human) P16388(Mouse) P10499(Rat) Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, IHC, IP, All Applications: WB:1:5,000-1:10,000 IHC:1:50-1:200 Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K⁺ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming -subunits (KVα), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KVβ subunits that modify the gating properties of the coexpressed KVα subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels. Purification and Purity: ProA affinity purified Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Specificity: Kv1.1 polyclonal antibody detects endogenous levels of Kv1.1 protein. Bioworld Molecular Weight: 56 kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Western blot analysis of Kv1.1 potassium channel on human brain lysates using anti-Kv1.1 potassium channel antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Kv1.1 potassium channel antibody. Counter stained with hematoxylin. Alternative Name: KCNA1, AEMK, EA1, Episodic ataxia with myokymia, HBK1, HUK1, Kca1 1, Kcna1, KCNA1, Kcpvd, KV1.1, MBK1, mceph, MGC124402, MGC126782, MGC138385, MK1, MK1, mouse, homolog of KV1.1, Potassium channel protein 1, Potassium voltage gated channel shaker related subfamily member 1, Potassium voltage gated channel subfamily A member 1, Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia), Potassium voltage-gated channel subfamily A member 1, RBK1, RCK1, Shak, Shaker related subfamily member 1, Voltage gated potassium channel subunit Kv1.1, Voltage-gated K(+) channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv1.1, Immunogen: recombinant protein Conjugate: Unconjugated Modification: Unmodified