Product Description

Kv3.1 Polyclonal Antibody

Catalogue Numbers: BS5779-50, BS5779-100

Sizes: 50µl, 100µl

Alternative Name: Potassium voltage-gated channel subfamily C member 1; NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4; KCNC1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P48547

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The human voltage-gated potassium (KV) channel KV3.1 gene maps to chromosome 11p15 and encodes a protein that resembles Drosophila Shaw subfamily channel types. KV channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KV channels are multimers that contain channel activity-dependent alpha subunits and modulatory gamma subunits. Neuronal populations in the CNS coexpressing KV3.1 and KV3.3 influence fast repolarization of action potentials and enable neurons to fire repetitively at high frequencies. KV3 genes produce multiple splice variants in the 3' ends of respective transcript, which may influence normal spatial ion permeability of excitable membranes in the brain.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Kv3.1 polyclonal antibody detects endogenous levels of Kv3.1 protein.

Bioworld Molecular Weight: ~ 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Kv3.1 polyclonal antibody at 1:500 dilution
Lane 1: Jurkat cell lysate
Lane 2: Raw264.7 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 254-299 of Human Kv3.1.

Conjugate: Unconjugated

Modification: Unmodified