Product Description

Kv7.1 Polyclonal Antibody

Catalogue Numbers: BS60208-50, BS60208-100

Sizes: 50µl, 100µl

Alternative Name: Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1; KCNQ1; KCNA8; KCNA9; KVLQT1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P51787

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an α subunit KCNQ1 and a β subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Kv7.1 polyclonal antibody detects endogenous levels of Kv7.1 protein.

Bioworld Molecular Weight: ~ 75 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Kv7.1 polyclonal antibody at 1:500 dilution
Lane 1: DLD whole cell lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Rat brain tissue lysate

Immunogen: A synthetic peptide corresponding to residues in Human Kv7.1.

Conjugate: Unconjugated

Modification: Unmodified