Product Description

Kv7.4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5773-50, BS5773-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Epilepsy affects about 0.5% of the world’s popμlation and has a large genetic component. Epilepsy resμlts from an electrical hyperexcitability in the central nervous system. Potassium channels are important regμlators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convμlsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap. Mutations of KCNQ4 affect the functions of sensory outer hair cells and lead to deafness.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Voltage-gated potassium channel subunit Kv7.4, KCNQ4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 650-695 of Human Kv7.4.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Kv7.4 polyclonal antibody detects endogenous levels of Kv7.4 protein.

Molecular Weight: ~ 77 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56696

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only