Lamin A/C Monoclonal Antibody-MB12098

Lamin A/C Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12098-50, MB12098-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P02545

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC-F, IHC-P, ICC/IF

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 74 kDa; Observed MW: 74,63 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of Lamin A/C in Hela using Lamin A/C antibody, and DAPI., Western blot analysis of Lamin A/C in 3T3, C2C12 lysates using Lamin A/C antibody., Western blot analysis of Lamin A/C in U251, Lncap, A549 lysates using Lamin A/C antibody, Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: LMNA; LMN1; Prelamin-A/C

Immunogen: A synthetic peptide of human Lamin A/C

Conjugate: Unconjugated

Modification: Unmodified