Product Description

Lamin A/C (Phospho-S392) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65001-50, BS65001-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P02545

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background: Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Lamin A/C (Phospho-S392) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser392.

Bioworld Molecular Weight: ~ 74, 65 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Lamin A/C (Phospho-S392) polyclonal antibody at 1:500 dilution
Lane A: DLD whole cell lysate
Lane B: The Kidney tissue lysate of Mouse
Lane C: The Lung tissue lysate of Rat

Alternative Name: Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen: Synthetic phosphopeptide derived from human Lamin A/C around the phosphorylation site of Serine 392.

Conjugate: Unconjugated

Modification: Phosphorylation