Lamin A Monoclonal Antibody - RA11594

Lamin A Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11594-50, RA11594-100

Citations, Manuals and MSDS Available upon request.

Background: lamin A/C (LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],

Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 4000

SWISS: P02545

Source: Mouse

Research Use Only