Product Description

Lamin B1 Mouse Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP1023M-50, AP1023M-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: An important part of the nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecμlar domain organisation with the other intermediate filament proteins in that they are fibrous molecμles that have an aminoterminal globμlar head, a central rod of alpha helices and a carboxy terminal globμlar domain. Many biochemical and molecμlar features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IHC, IF, IP

Alternate Names: Lamin-B1, LMNB1, LMN2, LMNB

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fμll length Human Lamin B1.

Dilution: WB: 1:5000~1:20000
IHC/IF: 1:50~1:200
IP: 1:50~1:200

Purification: The antibody was affinity-purified from cell cμlture supernatant by protein A+G and the purity is > 95% (by SDS-PAGE).

Specificity: Lamin B1 monoclonal antibody detects endogenous levels of Lamin B1 protein.

Molecular Weight: ~ 66 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P20700

Product: 2mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only