Product Description

LAMP2a Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90789-50, BS90789-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P13473(Human) P17047(Mouse) P17046(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200

Background: Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LAMP2a polyclonal antibody detects endogenous levels of LAMP2a protein.

Bioworld Molecular Weight: 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LAMP2a on different lysates using anti-LAMP2a antibody at 1/1,000 dilution.
Positive control:
Lane 1: Human placenta
Lane 2: JAR
Lane 3: Human liver, Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-LAMP2a antibody. Counter stained with hematoxylin.

Alternative Name: LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, CD107b, LAMP 2, Lamp 2a, LAMP-2, LAMP2, LAMP2, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified