LATH Polyclonal Antibody
Catalogue Numbers: BS60520-50, BS60520-100
Sizes: 50µl, 100µl
Alternative Name: Putative BPIFA4P protein; BPI fold containing family A, member 4, pseudogene; Breast cancer and salivary gland-expressed protein; Putative latherin; BPIFA4P; BASE; LATH
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q86YQ2
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: The PLUNC family of proteins are encoded by genes which map to chromosome 20 and are thought to play a potential role in the innate immune response in regions of the mouth, nose and lungs. As a member of the PLUNC family, BASE (breast cancer and salivary gland-expressed protein) is a 179 amino acid secreted protein that is named for its expression pattern. Due to its 63% sequence similarity with the related protein, Latherin, it is suggested that BASE is the major protein in sweat secretions and has important surfactant properties that lower surface tension. The expression pattern of BASE in many breast cancer cell lines suggests that it may be an easily accessible diagnostic breast cancer marker. Due to the fact that the gene encoding BASE is highly estrogen-repressed, expression of the gene is most likely dependent on HNF-3α and estrogen-mediated repression requiring ERα.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: LATH polyclonal antibody detects endogenous levels of LATH protein.
Bioworld Molecular Weight: ~ 19 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of LATH polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human LATH
Conjugate: Unconjugated
Modification: Unmodified