Latrophilin-1 rabbit pAb - ES5265

Latrophilin-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5265-50, ES5265-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],

Alternate Name: LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human LPHN1. AA range:561-610

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 22859

Human SWISS Prot NO: O94910

Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.

Research Use Only