LATS1/2 (Phospho-Ser909) Rabbit Polyclonal Antibody - BT-AP03378

LATS1/2 (Phospho-Ser909) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP03378-20, BT-AP03378-50, BT-AP03378-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner| with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity| indicating a role as a negative regulator of CDC2/cyclin A. In addition| the C-terminal kinase domain binds to its own N-terminal region| suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas| ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

Research Areas: Cancer; Cell biology

Target Protein: LATS1

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Serine/threonine-protein kinase LATS1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O95835; Mouse: Q8BYR2

Synonyms: Serine/threonine-protein kinase LATS1;EC 2.7.11.1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts; Serine/threonine-protein kinase LATS1; EC 2.7.11.1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts

GeneID: Human: 9113; Mouse: 16798

Research Use Only