Product Description

LATS1/2 (phospho-Ser909) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26823-50, RA26823-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: large tumor suppressor kinase 1 (LATS1) Homo sapiens The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)

Clonality: Polyclonal

Dilution: WB 1:1000-2000

Molecular Weight: 140

Protein Molecular Weight (kDa): 140

Storage: -20°C/1 year

Human Gene ID: 9113

Human SwissProt Number: O95835

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only