LC3 A/B rabbit pAb - ES20385

LC3 A/B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20385-50, ES20385-100

Citations, Manuals and MSDS Available upon request.

Background: function:Probably involved in formation of autophagosomal vacuoles (autophagosomes)., PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II., similarity:Belongs to the MAP1 LC3 family., subcellular location:LC3-II binds to the autophagic membranes., subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins., tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human LC3 A/B

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 14, 16kD

Human SWISS Prot NO: Q9H492/Q9GZQ8

Subcellular Location: Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton. LC3-II binds to the autophagic membranes.

Research Use Only