Product Description

LC3A Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90790-50, BS90790-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H492(Human) Q91VR7(Mouse) Q6XVN8(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IHC

All Applications: WB:1:500
ICC:1:50-1:200
IHC:1:50-1:200

Background: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LC3A polyclonal antibody detects endogenous levels of LC3A protein.

Bioworld Molecular Weight: 14/16 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LC3A on mouse brain and heart tissue lysates using anti-LC3A antibody at 1/200 dilution., ICC staining LC3A in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: MAP1A/MAP1B LC3 A, MAP1LC3A, MAP1A/MAP1B LC3 B, MAP1LC3B, MAP1ALC3, ATG8F, Autophagy related protein LC3 A, Autophagy related protein LC3 B, Autophagy related ubiquitin like modifier LC3 A, Autophagy related ubiquitin like modifier LC3 B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, LC3, MAP1 light chain 3 like protein 1, MAP1 light chain 3 like protein 2, MAP1 light chain 3-like protein 2, MAP1A/1B light chain 3 A, MAP1A/1B light chain 3 B, MAP1A/1BLC3, MAP1A/MAP1B LC3 A, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1BLC3, MAP1LC3A, Map1lc3b, Microtubule associated protein 1 light chain 3 alpha, Microtubule associated protein 1 light chain 3 beta, Microtubule associated proteins 1A/1B light chain 3, Microtubule associated proteins 1A/1B light chain 3A, Microtubule associated proteins 1A/1B light chain 3B, Microtubule-associated protein 1 light chain 3 beta, Microtubule-associated proteins 1A/1B light chain 3B, MLP3B,

Immunogen: Peptide

Conjugate: Unconjugated

Modification: Unmodified