Lck BP-1 (phospho Tyr397) rabbit pAb - ES5723

Lck BP-1 (phospho Tyr397) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5723-50, ES5723-100

Citations, Manuals and MSDS Available upon request.

Background: developmental stage:Expressed in early stage of myeloid and erythroid differentiation., function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression., PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells., similarity:Contains 1 SH3 domain., similarity:Contains 4 cortactin repeats., subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3., tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

Alternate Name: HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human HS1 around the phosphorylation site of Tyr397. AA range:366-415

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 55kD

Human Gene ID: 3059

Human SWISS Prot NO: P14317

Subcellular Location: Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.

Research Use Only