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LDHA/LDHB Polyclonal Antibody-BS90793

LDHA/LDHB Polyclonal Antibody-BS90793

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LDHA/LDHB Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90793-50, BS90793-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P00338(Human) P07195(Human) P06151(Mouse) P16125(Mouse) P04642(Rat) P42123(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat, zebrafish

Applications: WB, ICC/IF, IHC, IP, , FC

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:200-1:500
FC:1:50-1:100

Background: The lactate dehydrogenase family (LDH) catalyzes the final step of anaerobic glycolysis, the conversion of L-lactate and NAD to pyruvate and NADH. The LDH family consists of three members, LDH-A, LDH-B and LDH-C, all of which form tetramers consisting four subunits. However, each family member displays a specific tissue distribution pattern with LDH-A and LDH-B predominant in several tissues, specifically LDH-A in muscle and LDH-B in heart, while LDH-C expression is confined to the testis and sperm. LDHs function as powerful markers for germ cell tumors. The genes encoding human LDH-A and LDH-C map to chromosome 11, while the human LDH-B gene maps to chromosome 12. Deficiency in the LDH-A gene is linked to exertional myoglobinuria.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LDHA/LDHB polyclonal antibody detects endogenous levels of LDHA/LDHB protein.

Bioworld Molecular Weight: 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Lactate Dehydrogenase on different lysates using anti-Lactate Dehydrogenase antibody at 1/1,000 dilution.
Positive control:
Lane 1: Hela
Lane 2: A549
Lane 3: MCF-7, ICC staining Lactate Dehydrogenase in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: LDH-A, LDH-M, LDHA, PIG19, LDH-B, LDH-H, LDHB, Cell proliferation-inducing gene 19 protein, GSD11, L lactate dehydrogenase B chain, L-lactate dehydrogenase A chain, Lactate dehydrogenase A, Lactate dehydrogenase B, Lactate dehydrogenase H chain, Lactate dehydrogenase M, LDH A, LDH B, LDH H, LDH heart subunit, LDH M, LDH muscle subunit, LDH-A, LDH-M, LDH1, ldha, LDHA, LDHBD, LDHM, MS1111, PIG19, Proliferation inducing gene 19, Renal carcinoma antigen NY REN 46, Renal carcinoma antigen NY-REN-59, TRG 5, TRG5,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified