Product Description

LDOC1L Polyclonal Antibody

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Catalogue Numbers: BS67203-50, BS67203-100

Sizes: 50µl, 100µl

Swiss-Prot: Q6ICC9

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB, IHC

Background: LDOC1 is a 146 amino acid nuclear protein that contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is downregulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kB (NF-kB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. LDOC1L (Leucine zipper protein down-regulated in cancer cells-like), also known as MART6 (Mammalian retrotransposon-derived protein 6), is a 239 amino acid protein that belongs to the LDOC1 family.

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 164% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of LDOC1L protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LDOC1L expression in HEK293T (A), rat kidney (B), mouse brain (C) whole cell lysates., Immunohistochemical analysis of LDOC1L staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Bioworld Molecular Weight: ~ 26 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: MAR6; MART6; Protein LDOC1L; Leucine zipper protein down-regulated in cancer cells-like; Mammalian retrotransposon-derived protein 6

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LDOC1L. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified