Product Description

LEF-1 (F38) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3974-50, BS3974-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transcription factor that binds DNA in a sequence-specific manner.Participates in the Wnt signaling pathway (By similarity).Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity).PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1.Regμlates T-cell receptor alpha enhancer function.Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regμlator loci of BLK to modμlate expression (By similarity).May play a role in hair cell differentiation and follicle morphogenesis (By similarity).

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to Human LEF-1.

Dilution: WB: 1:1000~1:2000
IF: 1:100~1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: LEF-1 polyclonal antibody detects endogenous levels of LEF-1 protein.

Molecular Weight: ~ 52 kDa

Pathway: Adherens Junction signaling, Wntβ catenin signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UJU2

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only